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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMC4
All Species:
25.76
Human Site:
S117
Identified Species:
35.42
UniProt:
Q9NTJ3
Number Species:
16
Phosphosite Substitution
Charge Score:
-0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NTJ3
NP_001002800.1
1288
147182
S117
C
I
I
G
P
N
G
S
G
K
S
N
V
I
D
Chimpanzee
Pan troglodytes
XP_001157958
1288
147223
S117
C
I
I
G
P
N
G
S
G
K
S
N
V
I
D
Rhesus Macaque
Macaca mulatta
XP_001099428
1287
147121
G117
I
I
G
P
N
G
S
G
K
S
N
V
I
D
S
Dog
Lupus familis
XP_535848
1288
147094
S117
C
I
I
G
P
N
G
S
G
K
S
N
V
I
D
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG47
1286
146876
K117
I
G
P
N
G
S
G
K
S
N
V
I
D
S
M
Rat
Rattus norvegicus
Q9Z1M9
1233
143186
Y117
K
V
V
Q
L
H
E
Y
S
E
E
L
E
K
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510551
1069
122201
L36
D
I
I
G
S
G
R
L
K
D
P
I
E
V
L
Chicken
Gallus gallus
NP_989849
1274
145838
H134
Q
S
C
S
V
E
V
H
F
Q
K
I
I
D
K
Frog
Xenopus laevis
P50532
1290
146971
I117
G
S
G
K
S
N
V
I
D
S
M
L
F
V
F
Zebra Danio
Brachydanio rerio
NP_775360
1289
145687
G117
I
I
G
P
N
G
S
G
K
S
N
V
I
D
S
Tiger Blowfish
Takifugu rubipres
NP_001027927
1326
150958
V118
N
G
S
G
K
S
N
V
I
D
S
M
L
F
V
Fruit Fly
Dros. melanogaster
Q9VJE5
1690
189046
G132
I
G
Q
R
V
W
L
G
G
T
R
P
G
Q
I
Honey Bee
Apis mellifera
XP_396862
1282
148175
S117
I
S
V
L
I
H
N
S
S
E
H
Q
N
I
N
Nematode Worm
Caenorhab. elegans
Q20060
1549
176553
S125
S
I
I
G
P
N
G
S
G
K
S
N
L
I
D
Sea Urchin
Strong. purpuratus
XP_797583
1289
146235
S136
C
I
I
G
P
N
G
S
G
K
S
N
V
I
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJL0
1241
141112
Y117
I
D
L
E
N
G
L
Y
E
T
V
P
G
S
D
Baker's Yeast
Sacchar. cerevisiae
Q12267
1418
162171
S189
A
V
V
G
P
N
G
S
G
K
S
N
V
I
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.3
94
N.A.
89.5
24
N.A.
67.8
75.3
76.9
67.9
66.7
20.1
45.9
29.9
48.1
Protein Similarity:
100
99.6
98.9
96.5
N.A.
94.8
47.5
N.A.
75
86.3
87.5
83.5
81.2
40.2
63.9
47.5
65.4
P-Site Identity:
100
100
6.6
100
N.A.
6.6
0
N.A.
20
0
6.6
6.6
13.3
6.6
13.3
86.6
100
P-Site Similarity:
100
100
20
100
N.A.
13.3
26.6
N.A.
26.6
13.3
13.3
20
26.6
6.6
40
93.3
100
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.3
35.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
58.7
55.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
80
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
93.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
6
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
24
0
6
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
6
6
0
0
0
0
0
0
6
12
0
0
6
18
42
% D
% Glu:
0
0
0
6
0
6
6
0
6
12
6
0
12
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
6
0
0
0
6
6
6
% F
% Gly:
6
18
18
48
6
24
42
18
42
0
0
0
12
0
0
% G
% His:
0
0
0
0
0
12
0
6
0
0
6
0
0
0
0
% H
% Ile:
36
48
36
0
6
0
0
6
6
0
0
18
18
42
6
% I
% Lys:
6
0
0
6
6
0
0
6
18
36
6
0
0
6
6
% K
% Leu:
0
0
6
6
6
0
12
6
0
0
0
12
12
0
12
% L
% Met:
0
0
0
0
0
0
0
0
0
0
6
6
0
0
6
% M
% Asn:
6
0
0
6
18
42
12
0
0
6
12
36
6
0
6
% N
% Pro:
0
0
6
12
36
0
0
0
0
0
6
12
0
0
0
% P
% Gln:
6
0
6
6
0
0
0
0
0
6
0
6
0
6
0
% Q
% Arg:
0
0
0
6
0
0
6
0
0
0
6
0
0
0
0
% R
% Ser:
6
18
6
6
12
12
12
42
18
18
42
0
0
12
12
% S
% Thr:
0
0
0
0
0
0
0
0
0
12
0
0
0
0
0
% T
% Val:
0
12
18
0
12
0
12
6
0
0
12
12
30
12
6
% V
% Trp:
0
0
0
0
0
6
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
12
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _